Is Absolute Change in AlloMap More Informative Than Absolute Value?

PurposeIncreased variability in the non-invasive gene expression profiling (GEP) (AlloMap®) is associated with an increased risk of future events, but association absolute change below threshold GEP scores events has not yet been evaluated.MethodsPatients from Surveillance HeartCare Outcomes Registry (SHORE) score < 34 had test calculated. The event interest was a combination rejection (ISHLT ≥ 2R and/or AMR 1), death, and graft dysfunction (LVEF <40% or LVEF >=25% consecutive visit). Patients were divided into three groups: 1: Event - within 14 days event, 2: Prior 3 more tests over 30 prior to 3: No testing those no event. Group 1 2 are paired. N number x-axis label Figure patient each group.ResultsOf 2029 patients SHORE, there Event, 743 groups. Age, race, sex did differ significantly between median highest group (34.0), compared both (30.1) (30.7) groups, p<0.001. elevated ≥30 equivocal non-event control group, p = 0.25. GEP< different at time p=0.0046. (Figure 1)ConclusionGEP changes ahead clinical events. Absolute may add incremental prognostic information for beyond use value, especially 34. Further analysis necessary elucidate what AM be predictive Increased evaluated. group. Of 1)